Collagen ndi puloteni yofunikira yomwe imapereka dongosolo ndi chithandizo kumadera osiyanasiyana a thupi, kuphatikizapo khungu, mafupa, tendons, ndi mitsempha.Tikamakalamba, kupanga kolajeni kumachepa, zomwe zimayambitsa makwinya, kufooka kwa khungu, ndi kuuma kwa mafupa.